During a study, creatine monohydrate supplementation over ten weeks showed a synergistic effect on aerobic power.

Based on the magnitude inferences, consuming creatine immediately post-workout is superior to pre-workout vis-a-vis body composition and strength.

Preliminary studies indicate that creatine supplementation can increase brain creatine content in humans.

Subsequent studies have demonstrated that cognitive processing, either experimentally (following sleep deprivation) or naturally (due to aging) impaired, can be improved with creatine supplementation.